From Mopac and Highway 183: Go North on 183 to Anderson Mill Road and take a left.  Stay on Anderson Mill until you come to Highway 620.  At that intersection, Anderson Mill Road becomes FM 2769.  Continue on FM 2769 until you come to a 3-way stop (approximately 1 mile) and take a left.  Continue for approximately 1 more mile and you will see The Hearts and Paws facility on the left (look for sign). 

From Central & South Austin:  Go North on Mopac or Highway 360.  Take the 2222 exit toward Lakeway until you come to Highway 620.  Turn right and go 4 miles to intersection of 620 and Anderson Mill Road.  Turn left at the   intersection (road becomes FM 2769).  Continue on FM 2769 until you come to a 3-way stop (approximately 1 mile) and take a left.  Continue for approximately 1 more mile and you will see The Hearts and Paws facility on the left (look for sign).